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Why experts want to rename monkeypox


Monkeypox got its name in 1958, after researchers first identified it in a colony of laboratory monkeys in Denmark.

By Andrew Jacobs


Are monkeys spreading monkeypox to humans?


Researchers say the answer is no. But recently in Brazil, the unfounded fear that monkeys transmit the virus to people has spurred an outbreak of violence against marmosets and capuchin monkeys, leading to the death of at least seven animals, according to Brazilian officials.


The stoning and poisoning of wild primates in Brazil is an especially lurid example of how an inaptly named disease can have real-world implications.


Just as the so-called Spanish Flu of 1918 was not born on the Iberian Peninsula, the spread of monkeypox has little to do with monkeys. In fact, scientists say that rodents are the most likely animal reservoir for the virus, which is a cousin of smallpox that made its first recorded leap to humans decades ago in Congo. But in 1958, when Danish scientists first identified the virus in a colony of lab monkeys, they decided to bestow the naming honor on their captive primates.


In the three months since the first cases of monkeypox were reported in Europe and the United States, public health experts have been urging the World Health Organization to come up with new nomenclature that might help to clear up any confusion and reduce the shame and stigmatization associated with a disease that has been spreading largely among men who have sex with men.


“Names matter, and so does scientific accuracy, especially for pathogens and epidemics that we are trying to control,” said Tulio de Oliveira, a bioinformatician at Stellenbosch University in South Africa who has been among those pushing the WHO.


In June, de Oliveira and more than two dozen other scientists from across the African continent published an open letter urging the organization to move quickly. Failure to do so, they warned, risked hamstringing efforts to contain the disease.


The letter also condemned media coverage of the outbreak, noting that some Western outlets had been using photos of lesion-pocked Africans to illustrate an outbreak that was almost entirely affecting white men. Many articles have also been wrongly describing the virus as “endemic” to Africa, they wrote. In fact, before the current global outbreak, human-to-human transmission in Africa was relatively uncommon, with most infections occurring in rural areas among people who had direct contact with wild animals. “In the context of the current global outbreak, continued reference to, and nomenclature of this virus being African is not only inaccurate but is also discriminatory and stigmatizing,” the authors wrote.


The WHO has acknowledged the problem. In June, Director-General Tedros Adhanom Ghebreyesus said the organization would work with experts to find a new name, and last week, it issued a public call for suggestions. But many experts have grown impatient, saying the process has been too plodding given the disease’s rapid advance, which has now reached 92 countries, according to the WHO.


In a news conference last week, officials reported a 20% jump in cases over the previous week, with 35,000 cases, with the vast majority of infections concentrated in the Americas.


Many scientists have taken matters into their own hands and have begun using abbreviations such as “hMPXV” and “MPV” when writing or talking about the disease. There has been some progress in one aspect of the monkeypox nomenclature: A group of experts convened by the WHO agreed to rename two monkeypox virus variants, or clades, replacing geographical references — Congo Basin clade and West African clade with Roman numerals (Clade I and Clade II).


Monkeypox is more than just a misnomer. Many experts say the word evokes racist stereotypes, reinforces offensive tropes about Africa as a perilous, pestilence-filled continent and abets the kind of stigmatization that can prevent people from seeking medical care.


Dr. Ifeanyi Nsofor, a public health expert in Nigeria, said the dynamic with monkeypox was reminiscent of the early days of the AIDS crisis, when Africa was unfairly implicated in the global spread of the disease and many people hid their illness and did not seek medical help. “I still remember all the people dying unnecessarily,” said Nsofor, who is senior vice president for Africa at the Human Health Education and Research Foundation.


The fact that most of those recently infected with monkeypox are men who have sex with men only reinforces the fear and shame, especially in countries where homosexuality remains taboo and, in some cases, illegal.


Stigmatization surrounding a disease, he added, can have other insidious repercussions: National governments, worried about the impacts on tourism or foreign investment, can conceal outbreaks within their borders. African exchange students living abroad can be shunned or ridiculed.


The virus naming process, established in 2015, seeks to “minimize unnecessary negative impact of disease names on trade, travel, tourism or animal welfare, and avoid causing offense to any cultural, social, national, regional, professional or ethnic groups,” the WHO wrote at the time.


But these so-called best practices for naming new infectious diseases do not affect existing names that critics say have negative associations with actual places and people, like Rift Valley Fever, Middle East respiratory syndrome and Ebola, the hemorrhagic fever named for a river in Africa.


Changing existing virus names is another matter. The International Committee on Taxonomy of Viruses, which has a painstaking process for categorizing the multitude of known viruses, is responsible for assigning formal, scientific names. These are distinct from the common names of viruses.


Elliot J. Lefkowitz, a professor of microbiology and genetic bioinformatics at the University of Alabama at Birmingham and the organization’s data secretary, said it could likely take a year before the group’s members considered possible new names for the species into which monkeypox virus would be classified. Any new species name, he said, was likely to incorporate elements of the existing name to maintain a link with the past, a process separate from suggesting a new common name for the virus. “I don’t know of any virus name that’s actually been changed after it’s been used for years,” he said.


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