By Andrew Jacobs
It’s been more than five decades since Dustin Hoffman’s character in “The Graduate” was offered a kernel of wisdom about the path to prosperity.
“Plastics,” he’s told by Mr. McGuire, the starched corporate executive who offers the advice. “There’s a great future in plastics.”
Plastics have indeed been a game-changer for humanity, and the enormous range of cheap, durable plastic goods, from food containers and PVC pipes to polyester clothing and single-use medical products, have inarguably improved life.
The problem, as nearly everyone knows, is that plastics are forever, and very little of it has been recycled. The United Nations has estimated that most of the 400 million metric tons churned out annually — a doubling of production since 2000 — will remain on Earth in some form as the plastics are broken down into teeny specks by sunlight, wind and the sea.
Roughly 20 years ago, Richard Thompson, a marine biologist, discovered a worrisome accumulation of small plastic particles in ocean habitats and coined the word “microplastics.” Since then, scientists have been finding these fragments everywhere, from remote mountain peaks and the Arctic to the ocean seafloor.
In the decade that followed, scientists began to discover microplastics embedded in a wide range of living creatures, including in the seafood we eat. More recently, microplastics have been found inside the human body: in our lungs, our blood, our feces and in breast milk.
In 2021, Italian researchers for the first time identified microplastics in human placentas.
“Plastic People,” a new documentary directed by Ben Addelman and Ziya Tong, surveys the emerging science on microplastics and arrives at a troubling conclusion: The potential health risks associated with plastic pollution are becoming hard to ignore.
The film, scheduled to debut Saturday at the SXSW Film Festival in Austin, Texas, follows the work of microplastic researchers in a half-dozen countries, including a pair of Turkish scientists who said they recently discovered microplastics inside the human brain. Some of the particles were found deep inside the tissue of cancerous brain tumors.
“The revelation that the human body is full of microplastics is a recent one, and I think the implications will become one of the most dominant health and environmental stories of our time,” said Rick Smith, president of the Canadian Climate Institute and one of the film’s executive producers. “It doesn’t matter if you’re rich or poor; there’s no sheltering yourself from this kind of new pollution.”
Microplastics, fragments less than 5 millimeters in size that can usually be seen by the naked eye, are not to be confused with nanoplastics, which are smaller than a speck of dust and are often the inadvertent byproduct of plastic production. Research on the potential health effects of nanoplastics is still in its infancy, at least compared with the studies on microplastics, a field that has been rapidly expanding over the past few years.
Scientific evidence of the effects of microplastics on humans is limited, at least in peer-reviewed literature. A study in the journal Environmental Science & Technology in 2022 found that patients with inflammatory bowel disease had a significantly higher amount of microplastics in their feces than those without the disease. A small University of Hawaii study published last November cataloged the growing presence of microplastics in the placentas of new mothers.
And a paper published Thursday in the New England Journal of Medicine reported that people who had microplastics in their cardiovascular systems were at heightened risk for complications from heart attacks and strokes.
Nienke Vrisekoop, a microplastics researcher at the University Medical Center Utrecht in the Netherlands, said she found that immune cells that come in contact with microplastics die three times as quickly than those that do not. She said that the polystyrene commonly used to produce packing materials was especially toxic to the immune cells that consumed them.
Research conducted by another Dutch researcher, Barbro Melgert, found that microplastics inhibited the development of lung structures grown in her lab. Melgert, a respiratory immunologist at the University of Groningen, said nylon seemed to be most damaging to the lung structures. Polyvinyl chloride, or PVC, she discovered, was the least toxic of the plastics she tested.
Melgert is still trying to understand how microplastics affect living cells, but she suspects that the damage may be related to any number of chemicals that can leach from plastics into the human body.
Although she knows that the results of the study do not definitively prove harm to humans, nor do they quantify the risks, previous research on nylon factory workers showed extensive lung damage among those exposed to large amounts of nylon particles.
Foreign particulate matter like asbestos, coal dust or cigarette smoke often proves problematic to human health, she noted.
“If the particulate is organic and digestible, at least your body can break it down eventually and get rid of it,” Melgert said. “Plastic is different. It can just stay in the lung.”
The same can most likely be said for microplastics that find their way into the brain. The discovery, arguably the new film’s most significant revelation, was made by two Turkish researchers, Sedat Gündoğdu, a biologist, and Emrah Çeltikçi, a neurosurgeon.
Gündoğdu, a researcher at Cukurova University, has been studying microplastic pollution since 2016. Over the years, he has collaborated on scores of peer-reviewed studies documenting microplastics in fisheries, soil, table salt and intravenous fluid bags, and his alarm has grown with each new discovery.
It was only a matter of time, he said, before researchers would discover microplastics in the human brain. “It’s scary but not surprising,” he said.
Of the 15 samples examined so far, six plastic particles have been identified in tissue from two patients with tumors, Gündoğdu said. It was unclear how the fragments made their way into the brain, but he said that given the documented presence of microplastics in the blood, they most likely arrived via vessels feeding the tumors.
Despite the sense of urgency and doom conveyed by “Plastic People,” Tong, the co-director and a former host of the Discovery Channel science show “Daily Planet,” hopes the film can inspire change, the way “Silent Spring,” the 1962 book that documented the dangers of agricultural pesticides and helped lead to a ban on DDT, did.
On an individual level, that means encouraging consumers to reduce their reliance on single-use plastics, which make up 40% of global plastics production, she said.
But that also means persuading political leaders to take regulatory action. At the moment, Tong has her eye on a U.N. gathering next month in Ottawa, Ontario, where delegates from 175 countries will resume negotiations on a treaty proposal that would curb the explosive growth of plastic pollution. The talks have been snagged by industry opposition at times.
“It’s not like we need some remarkable new invention to address the problem,” Tong said. “We just have to use less plastic.”